1. Hu Guofang-中建协认证中心
Bevat niet: cssa | Resultaten tonen met:cssa
中建协认证中心
2. Alle hotels in Zhuhai
Alle hotels in Zhuhai. Beste selectie van hotels in Zhuhai met beoordelingen en kaarten. Reserveer vooraf en bespaar.
3. ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by ...
17 okt 2023 · This work identifies ALKBH5 as a key determinant of oocyte quality and unveil the facilitating role of ALKBH5-mediated m 6 A removal in maternal RNA decay.
N6-methyladenosine (m6A) maintains maternal RNA stability in oocytes. One regulator of m6A, ALKBH5, reverses m6A deposition and is essential in RNA metabolism. However, the specific role of ALKBH5 in oocyte maturation remains elusive. Here, we show that Alkbh5 depletion causes a wide range of defects in oocyte meiosis and results in female infertility. Temporal profiling of the maternal transcriptomes revealed striking RNA accumulation in Alkbh5−/− oocytes during meiotic maturation. Analysis of m6A dynamics demonstrated that ALKBH5-mediated m6A demethylation ensures the timely degradation of maternal RNAs, which is severely disrupted following Alkbh5−/− depletion. A distinct subset of transcripts with persistent m6A peaks are recognized by the m6A reader IGF2BP2 and thus remain stabilized, resulting in impaired RNA clearance. Additionally, reducing IGF2BP2 in Alkbh5-depleted oocytes partially rescued these defects. Overall, this work identifies ALKBH5 as a key determinant of oocyte quality and unveil the facilitating role of ALKBH5-mediated m6A removal in maternal RNA decay. N6-methyladenosine (m6A) maintains maternal RNA stability in oocytes. Here, the authors identify demethylase ALKBH5 as a key determinant of oocyte quality and unveil the facilitating role of ALKBH5-mediated m6A removal in maternal RNA decay.
4. [PDF] Navigating the Taiwan Strait - Belfer Center
Cold War, the strategic focus of the United States has shifted from Europe to. East Asia, in recognition of East Asia's growing economic importance and the.
5. Hu Guofang - Filmaffinity
La última noche en Tremor (Miniserie de TV); 2. La sustancia; 3. Venom: El último baile; 4. Casa en llamas; 5. Robot salvaje.
Usuarios
6. [PDF] Publications Contents Digest November/2024
Yanmo Hu;Kai Wu;J. Andrew Zhang;Weibo Deng;Y. Jay Guo. Publication Year: 2024 ... Yan Lu;Shaoshuai Gao;Mengyu Zhu;Guofang Tu. Publication Year: 2024,Page ...
7. Environmental Science – coronavirus research Home - RSC Publishing
Aerosol presence reduces the diurnal temperature range: an interval when the COVID-19 pandemic reduced aerosols revealing the effect on climate. Shijie Hu ...
42 items
8. [PDF] The Conversion of China´s Military-Nuclear Complex to Civilian ...
Only then, after much preparation and many precautions, a DF-2 (Dongfeng, or. East Wind, known in the West as. CSS-1) medium-range ballistic missile (MRBM) was ...
9. Numerical study on safety cognition of cavern constructors from ...
QIU Guofang , YU Xinshui . Safety cognition enhancement strategy of ... TONG Ruipeng, HU Xiangyang, WANG Leyao, HAN Jixiang. Risk zoo (Ⅳ): risk ...
To propose effective safety cognition strategies and reduce safety acc...
10. Clinical Effects of Microwave Ablation in the Treatment of Low-Risk ...
1, Guofang Chen. Guofang Chen. 1Endocrine and Diabetes Center, Affiliated ... Hu X, Qian L. A Comparative Study of Short-Term Efficacy and Safety for ...
This study aimed to evaluate the feasibility and efficacy of ultrasound-guided percutaneous microwave ablation (MWA) in the treatment of low-risk papillary thyroid microcarcinoma (PTMC), and to observe the histopathological changes after MWA. MWA ...
